Reproductive Case Study:

 

A 18-year-old female consulted a physician because she had never begun her menstrual cycle.  She had experienced normal breast development at age 12, but no pubic hair had appeared.  Height was 5ft, 6 inches, weight was 120 pounds, blood pressure was 110 / 70, and pulse was 60bpm.  General physical examination was normal and confirmed the presence of normal breast development.  The external genitalia were those of a normal female.  The vagina, however, ended in a blind pouch and no cervix was observed.  Neither ovaries nor uterus was felt.  Internal palpitation revealed a 1.5 cm mass on each side.

 

1.)  Compare the hormonal controls of the male reproductive cycle with the hormonal controls of the female reproductive cycle.  How are they the same?  How are they different?

2.) Could this individual have an XX sex chromosome karyotype?  If so, what might the diagnosis be?  What would be inconsistent with this diagnosis?

3.)  Could this individual have an XO sex chromosome karyotype?  What would be inconsistent with this diagnosis?

4.)  Could this individual have an XY sex chromosome karyotype?  If so, what diagnosis might explain her condition? 

5.)  For each of the above possibilities, what would be the hormone levels of estrogen, testosterone, LH, and FSH likely be?